Randstad Research Associate in Santa Monica, California
Santa Monica, CA
Friday, September 30, 2016
Randstad Life Sciences
Job Title: The Pharmacology team will evaluate in-house naked antibody cancer therapeutics including cancer immunotherapies and antibody drug conjugates (ADCs) in human tumor xenograft models and patient-derived xenograft models and syngeneic models.
- In addition to the pharmacology studies, the department also leads the preclinical Bio-Imaging efforts using Optical and micro PET/CT imaging modalities to evaluate therapeutic antibodies and ADCs and to support translational research efforts and mechanism of action studies.
Perform vivo tumor growth evaluation, efficacy and other in vivo studies.
Generate and characterize new human cancer xenografts derived from patient specimens and determine appropriate conditions for their growth both in vivo and in vitro
Evaluate patient-derived and cell line-derived xenograft models against Standard of Care agents.
Construct subcutaneous, orthotopic and other types of tumor xenograft models to validate the biological functions of cancer targets, and evaluate the efficacy of antibody therapeutics and antibody drug conjugates.
Develop humanized mouse models and evaluate immunotherapies using these models
Administer therapeutic agents through different routes (including intraperitoneal, intravenous and oral)
Monitor effects on tumor growth, metastasis, survival and overall animal health.
The ideal candidate should have a BS/MS in biological sciences with a minimum of 2 years of experience in biological research preferably in an industry setting.
Previous experience in handling research rodents, especially different strains of immunodeficient mice, is required.
Experiences in pre-clinical validation of cancer therapeutics using syngeneic and xenograft models.
Ability to statistically interpret data, draw conclusions from experimental results is required.
Effective trouble shooting and problem solving skills are required.
Must be able to work in a dynamic team environment
Ability to multi-task, handle multiple projects at one time.
Background in in vitro techniques is highly desirable.
Should not have animal allergies.
Medical, Dental, and Vision Insurance
401K Plan with Company Match
Life and AD&D Insurance